\u56fd\u9645\u6743\u5a01\u5b66\u672f\u671f\u520a\u300a\u81ea\u7136\u300b\u5728\u7ebf\u53d1\u8868\u4e86\u7f8e\u56fd\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u3001\u4e2d\u79d1\u9662\u4e0a\u6d77\u751f\u5316\u4e0e\u7ec6\u80de\u6240\/\u56fd\u5bb6\u86cb\u767d\u8d28\u79d1\u5b66\u4e2d\u5fc3\u2022\u4e0a\u6d77\uff08\u7b79\uff09\u5468\u754c\u6587\u7814\u7a76\u5458\u6240\u5e26\u9886\u8bfe\u9898\u7ec4\u7684\u6700\u65b0 \u6210\u679c\uff0c\u9996\u6b21\u89e3\u6790\u4e86\u4e19\u578b\u809d\u708e\u75c5\u6bd2\uff08hepatitis C virus\uff09\u611f\u67d3\u5bbf\u4e3b\u8fc7\u7a0b\u4e2d\u91cd\u8981\u79bb\u5b50\u901a\u9053\u86cb\u767dp7\u7684\u7cbe\u7ec6\u7a7a\u95f4\u7ed3\u6784\u4ee5\u53cap7\u4e0e\u6291\u5236\u5242\u91d1\u521a\u70f7\u80fa\u7c7b\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u5206\u5b50\u673a\u7406\u3002
\u3000\u3000\u4e19\u578b\u809d\u708e\u75c5\u6bd2\uff08HCV\uff09\u4e0e\u827e\u6ecb\u75c5\u75c5\u6bd2\uff08HIV\uff09\u3001\u6d41\u611f\u75c5\u6bd2\uff08influenza virus)\u4e00\u6837\uff0c\u5c5e\u4e8e\u5371\u5bb3\u6027\u5f3a\u7684RNA\u75c5\u6bd2\u3002\u4e19\u578b\u809d\u708e\u75c5\u6bd2\u6240\u5f15\u8d77\u7684\u75c5\u6bd2\u6027\u809d\u708e\uff0c\u662f\u6162\u6027\u809d\u708e\u7684\u4e3b\u8981\u75c5\u539f\u4e4b\u4e00\uff0c\u4e25\u91cd\u65f6\u4f1a\u5bfc\u81f4\u809d\u786c\u5316\u548c\u809d\u764c\u3002\u76ee\u524d\u4f30\u8ba1\u5168\u4e16\u754c\u6709 1\u4ebf7\u5343\u4e07\u4eba\u611f\u67d3HCV\uff0c\u6211\u56fd\u7684HCV\u643a\u5e26\u8005\u548c\u60a3\u8005\u603b\u6570\u5747\u5c45\u4e16\u754c\u9996\u4f4d\uff0c\u5c5e\u4e8e\u4e19\u809d\u9ad8\u53d1\u533a\uff0c\u8fc4\u4eca\u4e3a\u6b62\u8fd8\u6ca1\u6709\u7814\u53d1\u51fa\u6709\u6548\u63a7\u5236HCV\u7684\u9884\u9632\u6216\u6cbb\u7597\u6027\u75ab\u82d7\u3002<\/p>\n\n\n\n
\u3000\u3000\u957f\u671f\u4ee5\u6765\uff0c\u5bf9\u75c5\u4eba\u4f7f\u7528\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6cd5\u662f\u6301\u7eed\u6df7\u5408\u4f7f\u7528\u957f\u6548\u5e72\u6270\u7d20(peginterferon-\ufffd8\ufffd4)\u548c\u5229\u5df4\u97e6\u6797(ribavirin)\u3002\u4f46\u8fd9\u79cd\u6cbb \u7597\u65b9\u6cd5\u7597\u6548\u6709\u9650\u3001\u5468\u671f\u957f\u3001\u8d39\u7528\u6602\u8d35\uff0c\u5e76\u5e38\u4f34\u6709\u6bd2\u526f\u4f5c\u7528\u3002\u6700\u8fd1\u4ee5\u6807\u51c6\u7597\u6cd5\u8054\u7528\u65b0\u4e0a\u5e02\u7684NS3\/4A\u6291\u5236\u5242Telaprevir\u548cBoceprevir\u7b49\uff0c\u867d \u7136\u53ef\u4ee5\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\uff0c\u4f46\u6297\u836f\u6027\u7a81\u53d8\u75c5\u6bd2\u7684\u4ea7\u751f\u4e00\u76f4\u662f\u4e00\u4e2a\u6f5c\u5728\u7684\u95ee\u9898\u3002\u76ee\u524d\u56fd\u9645\u4e0a\u6297RNA\u75c5\u6bd2\u6cbb\u7597\u7684\u53d1\u5c55\u65b9\u5411\u662f\u5efa\u7acb\u4e00\u79cd\u57fa\u4e8e\u591a\u79cd\u836f\u7269\u9776\u70b9\u7684\u8054\u5408\u7597\u6cd5\uff0c\u56e0\u6b64\u8feb \u5207\u9700\u8981\u5f00\u53d1\u591a\u4e2a\u4f5c\u7528\u9776\u70b9\uff0c\u5bfb\u627e\u66f4\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u548c\u5e72\u9884\u624b\u6bb5\u3002<\/p>\n\n\n\n
\u3000\u3000p7\u662fHCV\u57fa\u56e0\u8868\u8fbe\u7684\u552f\u4e00\u7684\u79bb\u5b50\u901a\u9053\u86cb\u767d\uff0c\u5bf9\u75c5\u6bd2\u9897\u7c92\u7684\u7ec4\u88c5\u548c\u6210\u719f\u3001\u75c5\u6bd2\u9897\u7c92\u7684\u91ca\u653e\u5fc5\u4e0d\u53ef\u5c11\uff0c\u7a81\u53d8\u548c\u5b8c\u5168\u5220\u9664p7\u4f1a\u5bfc\u81f4HCV\u75c5\u6bd2\u4e0d\u80fd\u4ea7\u751f\u611f \u67d3\u6027\u3002\u79bb\u5b50\u901a\u9053\u86cb\u767d\u662f\u4e00\u7c7b\u5728\u8bb8\u591a\u75c5\u6bd2\u4e2d\u5e7f\u6cdb\u5b58\u5728\u7684\u86cb\u767d\u8d28\uff0c\u5bf9\u4e8e\u75c5\u6bd2\u7684\u751f\u6d3b\u5468\u671f\u4ea7\u751f\u91cd\u8981\u5f71\u54cd\uff0c\u88ab\u5e7f\u6cdb\u4f5c\u4e3a\u6f5c\u5728\u836f\u7269\u9776\u70b9\u52a0\u4ee5\u7814\u7a76\uff0c\u4f8b\u5982\u6d41\u611f\u75c5\u6bd2\u7684M2\u86cb\u767d\u548c\u827e \u6ecb\u75c5\u75c5\u6bd2\u7684Vpu\u86cb\u767d\u3002\u4f46\u662f\u4ee5p7\u4e3a\u9776\u70b9\u7684\u6297HCV\u836f\u7269\u7814\u7a76\u5374\u8fdb\u5c55\u7f13\u6162\uff0c\u4e3b\u8981\u539f\u56e0\u662f\u7531\u4e8ep7\u662f\u4e00\u4e2a\u8de8\u819c\u86cb\u767d\uff0c\u5f62\u6210\u591a\u805a\u4f53\u9633\u79bb\u5b50\u901a\u9053\u540e\uff0c\u7ed3\u6784\u590d\u6742\u3001\u6784\u8c61\u7075 \u6d3b\uff0c\u7ed9\u7ed3\u6784\u7814\u7a76\u3001\u5c24\u5176\u662f\u86cb\u767d\u8d28\u7ed3\u6676\u5e26\u6765\u6781\u5927\u56f0\u96be\uff0c\u56e0\u6b64\uff0c\u957f\u671f\u4ee5\u6765\u7f3a\u4e4fp7\u79bb\u5b50\u901a\u9053\u7684\u4e09\u7ef4\u7ed3\u6784\u53ca\u5176\u4e0e\u5c0f\u5206\u5b50\u5316\u5408\u7269\u7ed3\u5408\u7684\u4f5c\u7528\u673a\u7406\u3002<\/p>\n\n\n\n
\u3000\u3000\u5728\u65e0\u6cd5\u5f97\u5230\u86cb\u767d\u8d28\u6676\u4f53\u7684\u60c5\u51b5\u4e0b\uff0c\u5468\u754c\u6587\u7814\u7a76\u5458\u548c\u6b27\u9633\u6ce2\u535a\u58eb\uff08\u6587\u7ae0\u7b2c\u4e00\u4f5c\u8005\uff09\u5efa\u7acb\u4e86\u4e00\u79cd\u57fa\u4e8e\u6838\u78c1\u5171\u632f\u7684\u65b9\u6cd5\uff0c\u6700\u7ec8\u89e3\u6790\u4e86\u6b64\u75c5\u6bd2\u901a\u9053\u7684\u7ed3\u6784\u3002\u6b64\u901a\u9053 \u7ed3\u6784\u975e\u5e38\u7279\u5f02\uff0c\u5f62\u6210\u82b1\u74e3\u5f62\u7684\u516d\u805a\u4f53\u7ed3\u6784\uff0c\u662f\u76ee\u524d\u4f7f\u7528\u6838\u78c1\u5171\u632f\u6280\u672f\u89e3\u6790\u51fa\u7684\u6700\u5927\u7684\u79bb\u5b50\u901a\u9053\u7ed3\u6784\u3002\u7531\u7ed3\u6784\u5e26\u6765\u7684\u542f\u53d1\uff0c\u5468\u754c\u6587\u8bfe\u9898\u7ec4\u4e0e\u4e0a\u6d77\u5df4\u65af\u5fb7\u6240\u3001\u4e2d\u79d1\u9662\u4e0a\u6d77 \u751f\u5316\u7ec6\u80de\u6240\u5b59\u5175\u8bfe\u9898\u7ec4\u5408\u4f5c\uff0c\u9996\u6b21\u9274\u5b9a\u4e86\u91d1\u521a\u70f7\u80fa\u7c7b\u5316\u5408\u7269\u5bf9p7\u7684\u79bb\u5b50\u901a\u9053\u6d3b\u6027\u53d1\u6325\u6291\u5236\u4f5c\u7528\u7684\u7ed3\u5408\u4f4d\u70b9\uff0c\u5e76\u901a\u8fc7\u4e00\u7cfb\u5217\u7684\u529f\u80fd\u6d4b\u8bd5\uff0c\u63ed\u793a\u4e86p7\u901a\u9053\u79bb\u5b50\u8f6c\u8fd0\u548c \u836f\u7269\u6291\u5236\u7684\u673a\u7406\u3002<\/p>\n\n\n\n
\u3000\u3000\u901a\u8fc7\u5bf9\u8fd9\u4e9b\u75c5\u6bd2\u79bb\u5b50\u901a\u9053\u7ed3\u6784\u548c\u673a\u5236\u65b9\u9762\u7684\u7406\u89e3\uff0c\u79d1\u5b66\u5bb6\u671f\u671b\u5728\u4e0d\u4e45\u7684\u5c06\u6765\u53ef\u4ee5\u7814\u5236\u51fa\u65b0\u4e00\u4ee3\u6297\u4e19\u578b\u809d\u708e\u75c5\u6bd2\u7684\u6cbb\u7597\u624b\u6bb5\u3002<\/p>\n\n\n\n
\u3000\u3000\u672c\u8bfe\u9898\u7814\u7a76\u7ec4\u8d1f\u8d23\u4eba\u5468\u754c\u6587\u7814\u7a76\u5458\uff0c\u73b0\u4e3a\u7f8e\u56fd\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u6559\u6388\u3001\u4e2d\u7ec4\u90e8\u201c\u5343\u4eba\u8ba1\u5212\u201d\u5f15\u8fdb\u4eba\u624d\u3001\u4e2d\u79d1\u9662\u4e0a\u6d77\u751f\u5316\u4e0e\u7ec6\u80de\u6240\/\u56fd\u5bb6\u86cb\u767d\u8d28\u79d1\u5b66\u4e2d\u5fc3\u2022\u4e0a \u6d77\uff08\u7b79\uff09\u7814\u7a76\u5458\u3002\u5176\u8bfe\u9898\u7ec4\u7684\u7814\u7a76\u4e13\u957f\u662f\u7528\u751f\u7269\u7269\u7406\u65b9\u6cd5\u6d4b\u819c\u86cb\u767d\u7ed3\u6784\u4e0e\u52a8\u6001\u7279\u6027\uff0c\u7406\u89e3\u5b83\u4eec\u7684\u529f\u80fd\u4e0e\u673a\u5236\uff0c\u5c24\u5176\u5728\u75c5\u6bd2\u86cb\u767d\u8d28\u7814\u7a76\u65b9\u9762\u5177\u6709\u5f88\u6df1\u539a\u7684\u79ef\u7d2f\u3002\u5728\u6b64\u4e4b \u524d\uff0c\u4e5f\u662f\u8fd9\u4e2a\u8bfe\u9898\u7ec4\u9996\u6b21\u89e3\u6790\u4e86\u79bd\u6d41\u611f\u75c5\u6bd2\u79bb\u5b50\u901a\u9053\u7684\u7ed3\u6784\u4e0e\u8010\u836f\u673a\u5236\uff08\u6210\u679c\u53d1\u8868\u5728Nature\uff0cPNAS\u7b49\u9876\u5c16\u5b66\u672f\u520a\u7269\u4e0a\uff09\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
\u56fd\u9645\u6743\u5a01\u5b66\u672f\u671f\u520a\u300a\u81ea\u7136\u300b\u5728\u7ebf\u53d1\u8868\u4e86\u7f8e\u56fd\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u3001\u4e2d\u79d1\u9662\u4e0a\u6d77\u751f\u5316\u4e0e\u7ec6\u80de\u6240\/\u56fd\u5bb6\u86cb\u767d\u8d28\u79d1\u5b66\u4e2d\u5fc3\u2022\u4e0a …<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[5],"class_list":["post-27","post","type-post","status-publish","format-standard","hentry","category-doc","tag-hcv"],"_links":{"self":[{"href":"http:\/\/www.polaris-bio.com\/wp-json\/wp\/v2\/posts\/27","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.polaris-bio.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.polaris-bio.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.polaris-bio.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.polaris-bio.com\/wp-json\/wp\/v2\/comments?post=27"}],"version-history":[{"count":1,"href":"http:\/\/www.polaris-bio.com\/wp-json\/wp\/v2\/posts\/27\/revisions"}],"predecessor-version":[{"id":28,"href":"http:\/\/www.polaris-bio.com\/wp-json\/wp\/v2\/posts\/27\/revisions\/28"}],"wp:attachment":[{"href":"http:\/\/www.polaris-bio.com\/wp-json\/wp\/v2\/media?parent=27"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.polaris-bio.com\/wp-json\/wp\/v2\/categories?post=27"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.polaris-bio.com\/wp-json\/wp\/v2\/tags?post=27"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}